Intended use

This immunoassay kit allows for the for the in vitro quantitative determination of the activity of  a1-AT in plasma and other biological fluids.

 

Introduction

α1-antitrypsin, an acute phase protein, is the prototypic member of the serpin super family and a major inhibitor of serine proteases. As an acute phase protein, α1-antitrypsin is thought to play an important role in limiting host tissue injury at sites of inflammation. The clinical importance of α1-antitrypsin is highlighted in individuals with inherited α1- antitrypsin deficiency who exhibit an increased susceptibility to develop chronic inflammatory conditions including chronic obstructive pulmonary disease, systemic vasculitis and necrotizing panniculitis.